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  • Title: Efficient Enantioselective Syntheses of (+)-Dalesconol A and B.
    Author: Zhao G, Xu G, Qian C, Tang W.
    Journal: J Am Chem Soc; 2017 Mar 08; 139(9):3360-3363. PubMed ID: 28225267.
    Abstract:
    We herein report the first enantioselective syntheses of immunosuppressants (+)-dalesconol A and B in a highly efficient and concise manner, which features an efficient palladium-catalyzed enantioselective dearomative cyclization-kinetic resolution cascade to install the chiral all-carbon quaternary center, an effective sterically hindered Stille coupling, a powerful 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) oxidation to furnish all requisite unsaturation, and a tandem hydrolysis-ring closure sequence.
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