These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Hypothalamo-pituitary-interrenal responses to opioid substances in the trout. II. Effects of morphine and D-Ala2, Met5-enkephalinamide on plasma cortisol titres in vivo.
    Author: Mukherjee S, Baker BI, Bird DJ, Buckingham JC.
    Journal: Gen Comp Endocrinol; 1987 Oct; 68(1):40-8. PubMed ID: 2822527.
    Abstract:
    The influence of morphine, D-Ala2, Met5-enkephalinamide (DALA), and naloxone on plasma cortisol titres has been studied in vivo in fingerling and adult trout. The responses were complex and variable. A single ip injection of morphine or DALA into fingerlings usually resulted in a rise in plasma cortisol after 0.5 hr followed by a fall below control values within 2 hr. In similar experiments with adult trout, only an inhibitory effect was observed. Naloxone reduced the rise in plasma cortisol following saline injection, but only when the hypothalamo-pituitary-interrenal response was intense. The antagonist also blocked the morphine-induced rise in cortisol secretion. Prolonged morphine treatment diminished both the postinjection and stress-induced secretion of cortisol in adult fish. Morphine had no effect on the spontaneous or ACTH-induced secretion of cortisol by interrenal tissue incubated in vitro. The results support the concept of inhibitory and stimulatory sites of action by opiates and opioid substances on the hypothalamo-pituitary-interrenal axis. These findings are discussed with reference to the action of morphine on hypothalamic and pituitary tissue of the trout in vitro and with the opioid control of hypothalamo-pituitary-adrenal function in mammals.
    [Abstract] [Full Text] [Related] [New Search]