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  • Title: The effect on newborn chicks of oral inoculation of reovirus isolated from chickens with tenosynovitis.
    Author: Tang KN, Fletcher OJ, Villegas P.
    Journal: Avian Dis; 1987; 31(3):584-90. PubMed ID: 2823775.
    Abstract:
    Reovirus strain 176, isolated from chickens with tenosynovitis, was highly pathogenic following oral inoculation of 1-day-old specific-pathogen-free chicks. Disseminated lesions including hepatic necrosis, splenic lymphostromal cell hyperplasia, and bursal atrophy occurred on day 3 postinoculation (PI), followed by myocarditis on day 6 PI and by pericarditis and tenosynovitis on day 9 PI. Reovirus was isolated from the liver as early as day 1 PI, whereas significant neutralizing antibody was detected on day 13 PI. Mortality occurred from day 4 to day 7 PI, and the death of birds was associated with the severity of hepatic necrosis. The occurrence of tenosynovitis in virus-inoculated birds was subclinical.
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