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  • Title: Presence of functional receptors for atrial natriuretic peptide in human pheochromocytoma.
    Author: Shionoiri H, Hirawa N, Takasaki I, Ishikawa Y, Minamisawa K, Miyajima E, Kinoshita Y, Shimoyama K, Shimonaka M, Ishido M.
    Journal: Biochem Biophys Res Commun; 1987 Oct 14; 148(1):286-91. PubMed ID: 2823805.
    Abstract:
    Pheochromocytoma, a catecholamine-secreting adrenomedullary tumor, has been shown to contain the functional receptor for human atrial natriuretic peptide(h-ANP). Release of catecholamines from tissue slices of pheochromocytoma was inhibited by h-ANP in a dose-dependent manner. Binding assays using 125I-ANP revealed a single class of high affinity binding sites for ANP. When covalently tagged with 125I-ANP and electrophoresed under non-reducing and reducing conditions, the receptor migrated as a 140-kDa band and a 70-kDa band, respectively, reflecting its disulfide-linked subunit structure. The presence of ANP receptor in pheochromocytoma was further demonstrated by immunohistochemistry; the tumor was positively stained with an antireceptor antiserum. The antiserum was also useful to establish the zona glomerulosa localization of ANP receptor in the normal human adrenal gland.
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