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  • Title: [Combined action of nucleosides and alpha-interferon in inhibiting the reproduction of the herpes simplex type-II virus].
    Author: Temicheva EV, Malinovskaia VV, Manakhova LS, Mironova LL, Galegov GA.
    Journal: Biull Eksp Biol Med; 1987 Oct; 104(10):490-2. PubMed ID: 2823929.
    Abstract:
    Therapeutic effect of four combinations of antiherpetic chemical preparations--acyclovir (ACV), 9-beta-D-arabinofuranosyladenine (ARA-A) and E-5-(2-bromovinyl)-2'-desoxyuridine (BVDU)--has been studied. Mutual enhancement was observed in all the combinations studied, except for ACV and ARA-A combination, where partial antagonism was observed. ACV + BVDU was shown to be the most optimal combination, with the minimum inhibitory concentration (MIC) of BVDU decreasing 400-fold. A significant enhancement of nucleosides antiviral effect was noted when the human leucocyte interferon was used with the combinations. Along with synergistic effect during the interaction of alpha-interferon with ACV the antagonism in the combination of alpha-interferon with ARA-A was observed.
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