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  • Title: Receptor-phosphoinositidase C coupling. Multiple G-proteins?
    Author: Lo WW, Hughes J.
    Journal: FEBS Lett; 1987 Nov 16; 224(1):1-3. PubMed ID: 2824238.
    Abstract:
    Recent evidence has suggested that receptor-mediated phosphoinositide turnover, like that of the adenylate cyclase cAMP pathway, is regulated by guanine nucleotides. It is likely that one or more guanine nucleotide-binding proteins (G-proteins) couple calcium-mobilizing receptors to the activation of phosphoinositidase C. Recent studies utilizing various bacterial toxins have strongly suggested the presence of multiple G-proteins in the regulation of receptor-phosphoinositidase C coupling in a variety of cell types.
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