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  • Title: Map location of the thymidine kinase gene of bovine herpesvirus 1.
    Author: Bello LJ, Whitbeck JC, Lawrence WC.
    Journal: J Virol; 1987 Dec; 61(12):4023-5. PubMed ID: 2824831.
    Abstract:
    Bovine herpesvirus 1 has been reported to contain a thymidine kinase (tk) gene which is nonessential for virus replication. We have isolated a thymidine kinase-negative mutant of the virus and localized the mutation by marker rescue experiments to a 1.1-kilobase BglII-SalI fragment which maps at 0.47 to 0.48 on the bovine herpesvirus 1 genomic map. A thymidine kinase-negative bovine cell line isolated in our laboratory was used in these studies.
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