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  • Title: Suppression of RNA synthesis by a specific antiviral activity in Sindbis virus-infected Aedes albopictus cells.
    Author: Condreay LD, Brown DT.
    Journal: J Virol; 1988 Jan; 62(1):346-8. PubMed ID: 2824854.
    Abstract:
    An antiviral protein is released by mosquito cells persistently infected with Sindbis virus. Differences in both sensitivity to and production of this virus-specific activity were apparent in three independently produced Aedes albopictus cell lines. This activity inhibits total viral RNA synthesis in a time-dependent manner. The antiviral effect is maximally realized when cells are treated with the activity 48 h before infections. These data suggest that the antiviral activity induces an antiviral state in treated cells which prevents the formation or efficient function of viral RNA-synthesizing complexes.
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