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  • Title: Effect of potassium on renal acidification and acid-base homeostasis.
    Author: Tannen RL.
    Journal: Semin Nephrol; 1987 Sep; 7(3):263-73. PubMed ID: 2825318.
    Abstract:
    In summary, altered potassium homeostasis can modify bicarbonate reabsorption by the proximal tubule and alter acidification by the distal nephron both by affecting proton transport in a primary fashion and by modifying renal ammonia production. With physiologic variations in dietary K+ intake, these processes may serve to sustain concurrent potassium and acid-base homeostasis. However, with pathologic degrees of potassium depletion and hyperkalemia, metabolic alkalosis and acidosis, respectively, can result.
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