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  • Title: Maffucci's syndrome complicated by carcinoma of the breast, pituitary adenoma, and mediastinal hemangioma.
    Author: Marymont JV, Fisher RF, Emde GE, Limbird TJ.
    Journal: South Med J; 1987 Nov; 80(11):1429-31. PubMed ID: 2825361.
    Abstract:
    We have described a 39-year-old woman with Maffucci's syndrome, large mediastinal hemangiomas, infiltrating adenocarcinoma of the breast, and pituitary adenoma. This is the fifth reported case of Maffucci's syndrome with a coexistent pituitary adenoma, a frequency that cannot be explained by chance alone. There has been only one previously reported case in which the patient had a widened mediastinum, but the etiology was not discussed. Three of the four previously described patients with Maffucci's syndrome and a pituitary adenoma also had a proven or possible associated epithelial neoplasm. While this association is tenuous, it is considered worthy of comment.
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