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  • Title: Activation of herpes simplex virus 1 gamma 2 genes by viral DNA replication.
    Author: Mavromara-Nazos P, Roizman B.
    Journal: Virology; 1987 Dec; 161(2):593-8. PubMed ID: 2825424.
    Abstract:
    The expression of gamma 2 or true gamma genes resident in the herpes simplex virus 1 genome requires functional products of genes expressed earlier in infection and viral DNA synthesis. To determine whether the requirement for viral DNA synthesis for the expression of gamma 2 genes reflects a trans-acting function of a product of one or a few genes made or activated during viral DNA synthesis or whether it reflects a cis effect of DNA synthesis at specific sites, 143 thymidine kinase (TK) minus cells were sequentially infected with a virus carrying a 700-bp deletion of the TK gene and 6 hr later with wild-type or recombinant viruses carrying an alpha-TK or a gamma 2-TK gene in either the presence or absence of viral DNA synthesis. These experiments indicated that the gamma 2-TK gene contained in an unreplicated viral genome was not expressed by trans-acting factors specified before and during DNA synthesis by the first infecting virus, and, therefore, the induction of gamma 2 genes appears to be mediated by a cis-acting function associated with viral DNA synthesis.
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