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  • Title: Effect of an inhibitor of protein kinase C on human polymorphonuclear leukocyte degranulation.
    Author: Salzer W, Gerard C, McCall C.
    Journal: Biochem Biophys Res Commun; 1987 Oct 29; 148(2):747-54. PubMed ID: 2825670.
    Abstract:
    The protein kinase C inhibitor C-I reduced superoxide production by human neutrophils in response to phorbol myristate acetate by greater than 50%. In contrast to its effects in oxidative metabolism, 100 microM C-I caused minimal inhibition (5-18%) of lysozyme release in response to phorbol myristate acetate. Enzyme release produced by the formylated oligopeptide FMLP was enhanced by 23-54% in neutrophils pretreated with 100 microM C-I. These findings suggest that protein kinase C activation is not required for phorbol myristate acetate induced enzyme release. Enhancement of FMLP stimulated degranulation by C-I suggests that protein kinase C activation may have inhibitory effects on the release of granule enzymes by human neutrophils.
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