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  • Title: Enhanced adhesion of Streptococcus mutans to hydroxyapatite after exposure to saliva.
    Author: Spengler C, Thewes N, Nolle F, Faidt T, Umanskaya N, Hannig M, Bischoff M, Jacobs K.
    Journal: J Mol Recognit; 2017 Jul; 30(7):. PubMed ID: 28256775.
    Abstract:
    Streptococcus mutans cells form robust biofilms on human teeth and are strongly related to caries incidents. Hence, understanding the adhesion of S. mutans in the human oral cavity is of major interest for preventive dentistry. In this study, we report on atomic force microscopy-based single-cell force spectroscopy measurements of S. mutans cells to hydroxyapatite surfaces. We observe for almost all measurements a significant difference in adhesion strength for S. mutans as well as for Staphylococcus carnosus cells. However, the increase in adhesion strength after saliva exposure is much higher for S. mutans cells compared to S. carnosus cells. Our results demonstrate that S. mutans cells are well adapted to their natural environment, the oral cavity. This ability promotes the biofilm-forming capability of that species and hence the production of caries-provoking acids. In consequence, understanding the fundamentals of this mechanism may pave a way towards more effective caries-reducing techniques.
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