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  • Title: Synthesis and binding study on pyrazolo[4,5-c] [1,8]naphthyridines.
    Author: Cecchi L, Colotta V, Filacchioni G, Melani F, Palazzino G, Galli A.
    Journal: Farmaco Sci; 1987 Sep; 42(9):671-80. PubMed ID: 2826226.
    Abstract:
    Following our previous reports on pyrazolo[4,5-c]quinoline derivatives some isosteric pyrazolo[4,5-c] [1,8]naphthyridines were synthesized and tested for their ability to displace [3H]flunitrazepam from rat brain membranes. The lack of activity of the synthesized compounds and structure-activity relationships for the whole series are discussed.
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