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  • Title: Diagnosis of Zika virus infection on a nanotechnology platform.
    Author: Zhang B, Pinsky BA, Ananta JS, Zhao S, Arulkumar S, Wan H, Sahoo MK, Abeynayake J, Waggoner JJ, Hopes C, Tang M, Dai H.
    Journal: Nat Med; 2017 May; 23(5):548-550. PubMed ID: 28263312.
    Abstract:
    We developed a multiplexed assay on a plasmonic-gold platform for measuring IgG and IgA antibodies and IgG avidity against both Zika virus (ZIKV) and dengue virus (DENV) infections. In contrast to IgM cross-reactivity, IgG and IgA antibodies against ZIKV nonstructural protein 1 (NS1) antigen were specific to ZIKV infection, and IgG avidity revealed recent ZIKV infection and past DENV-2 infection in patients in dengue-endemic regions. This assay could enable specific diagnosis of ZIKV infection over other flaviviral infections.
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