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  • Title: Deletion and duplication variants around the long repeats of herpes simplex virus type 1 strain 17.
    Author: MacLean AR, Brown SM.
    Journal: J Gen Virol; 1987 Dec; 68 ( Pt 12)():3019-31. PubMed ID: 2826647.
    Abstract:
    Three variants of herpes simplex virus type 1 strain 17 were isolated. One variant had a deletion of 2.5 X 10(6) Mr in IRL/UL and 0.8 X 10(6) Mr in TRL such that sequences were deleted from both long repeats. The deletion in UL removed the 20K and 22K open reading frames. The second variant had a deletion of 3.5 X 10(6) Mr in IRL/UL which again removed the 20K and 22K open reading frames. The third variant had a similar deletion in UL, but in this case the deleted sequences were replaced by sequences from the left end of UL, such that the long repeat was extended by 3 X 10(6) Mr and the overall genome size by 2 X 10(6) Mr. All three variants grew almost normally in vitro. The analysis of 11 isolates with extensive variation in the long repeats outside the 'a' sequence is also reported.
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