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  • Title: The effect of hydroxyl radical scavenging on acute axial-random skin flap survival.
    Author: Hayden RE, Paniello RC, Yeung CS, Bello SL.
    Journal: Laryngoscope; 1988 Jan; 98(1):106-8. PubMed ID: 2826943.
    Abstract:
    Dimethyl thiourea (DMTU), a known hydroxyl radical scavenger, was tested for its ability to improve survival in acute island skin flaps. Rats receiving 500 mg/kg DMTU 1 hour after flap elevation showed a 23.5% improved survival over saline controls. The role of the hydroxyl radical in ischemia/reperfusion injury, and its proposed mechanism, is discussed.
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