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  • Title: Water as a Hydride Source in Palladium-Catalyzed Enantioselective Reductive Heck Reactions.
    Author: Kong W, Wang Q, Zhu J.
    Journal: Angew Chem Int Ed Engl; 2017 Mar 27; 56(14):3987-3991. PubMed ID: 28272769.
    Abstract:
    Pd-catalyzed intramolecular asymmetric carbopalladation of N-aryl acrylamides followed by reduction of C(sp3 )-Pd intermediate using diboron-water as a hydride source afforded enantioenriched 3,3-disubstituted oxindoles in high yields and enantioselectivities. When heavy water was used as a deuterium donor in combination with bis(catecholato)diboron (Cat2 B2 ), deuterium was incorporated into the products with high synthetic efficiency. The ligand determined both the enantioselectivity of the reaction and the reaction pathways, thereby affording either hydroarylation (reductive Heck) or carboborylation products.
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