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  • Title: Antagonistic adrenergic-muscarinic regulation of M current in smooth muscle cells.
    Author: Sims SM, Singer JJ, Walsh JV.
    Journal: Science; 1988 Jan 08; 239(4836):190-3. PubMed ID: 2827305.
    Abstract:
    The beta-adrenergic agonist isoproterenol and analogs of adenosine 3',5'-monophosphate (cAMP) induced a potassium current, M current, in freshly dissociated gastric smooth muscle cells. Muscarinic agonists suppress this current, apparently by acting at a locus downstream from regulation of cAMP levels by adenylate cyclase and phosphodiesterase. Thus, M current can be induced by an agent and regulated in antagonistic fashion by beta-adrenergic and muscarinic systems.
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