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  • Title: Peptide Metal-Organic Frameworks for Enantioselective Separation of Chiral Drugs.
    Author: Navarro-Sánchez J, Argente-García AI, Moliner-Martínez Y, Roca-Sanjuán D, Antypov D, Campíns-Falcó P, Rosseinsky MJ, Martí-Gastaldo C.
    Journal: J Am Chem Soc; 2017 Mar 29; 139(12):4294-4297. PubMed ID: 28274119.
    Abstract:
    We report the use of a chiral Cu(II) 3D metal-organic framework (MOF) based on the tripeptide Gly-l-His-Gly (GHG) for the enantioselective separation of metamphetamine and ephedrine. Monte Carlo simulations suggest that chiral recognition is linked to preferential binding of one of the enantiomers as a result of either stronger or additional H-bonds with the framework that lead to energetically more stable diastereomeric adducts. Solid-phase extraction of a racemic mixture by using Cu(GHG) as the extractive phase permits isolating >50% of the (+)-ephedrine enantiomer as target compound in only 4 min. To our knowledge, this represents the first example of a MOF capable of separating chiral polar drugs.
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