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  • Title: [Role of Ca-calmodulin- and cAMP-dependent reactions in forming the cardiac cycle].
    Author: Laptev BI, Prokop'eva VD, Bogomaz SA.
    Journal: Nauchnye Doki Vyss Shkoly Biol Nauki; 1987; (10):63-72. PubMed ID: 2827793.
    Abstract:
    The mechanisms of regulation of calcium ion concentration in the heart muscle during cardiac cycle have been considered. A great deal of attention has been devoted to the interaction of Ca2+-calmodulin- and cAMP-dependent reactions in the heart contraction-relaxation processes. The hypothesis on the two-phase structure of cardiac cycle has been proposed. This hypothesis allows to explain some biochemical mechanisms in the positive inotropic effect of catecholamines, cardiac glycosides and caffeine.
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