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  • Title: Effects of Remineralization Agents on Artificial Carious Lesions.
    Author: Savas S, Kucukyilmaz E, Celik EU.
    Journal: Pediatr Dent; 2016 Nov 15; 38(7):511-518. PubMed ID: 28281957.
    Abstract:
    PURPOSE: The purpose of this study was to evaluate the remineralization potentials of different agents on demineralized enamel surfaces. METHODS: Four hundred and sixty extracted human molars with artificial carious lesions were divided into six groups: (1) control; (2) acidulated phosphate fluoride (APF); (3) Curodont Repair (CR); (4) silver diamine fluoride (SDF); (5) ammonium hexafluorosilicate (SiF); and (6) SiF plus cetylpiridinium chloride (SiF+CPC). They were subdivided according to immersion periods (seven out of 30 days). After demineralization and remineralization procedures, microhardness test (VHN), energy-dispersive X-ray spectroscopy analysis, and confocal laser scanning microscopy evaluation were performed. The data were statistically analyzed. RESULTS: By the 30-day remineralization, the mean differences in VHN values were ranked as follows, in order: (1) CR; (2) APF; (3) SiF; (4) SiF+CPC; (5) SDF; and (6) control (P<0.05). The calcium (Ca) content and calcium/phosphate ratio for all groups were significantly higher after 30 days (P<0.05). The greatest lesion depth changes were observed in the CR, APF, SiF, and SDF groups (P<0.05), while the greatest fluorescence changes were observed in the APF, SiF, and CR groups (P<0.05). CONCLUSIONS: The remineralization was most successful in the CR, APF, and SiF groups, with higher values than for those of the other treatments.
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