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  • Title: The molecular basis of HbH disease in Taiwan.
    Author: Peng HW, Han SH, Chow TY, Ho CH, Ching KN, Chiang BN.
    Journal: Hum Genet; 1988 Feb; 78(2):137-9. PubMed ID: 2828223.
    Abstract:
    We have determined the molecular characteristics of alpha-thalassemia in 12 HbH subjects from Taiwan by restriction endonuclease mapping with alpha- and zeta-specific probes. We have found four types of defects in the alpha-thalassemia-2 genetic determinant: -alpha 3.7 type I; -alpha 4.2; alpha CS alpha; and alpha alpha T. All HbH subjects carried the --SEA genotype in the alpha-thalassemia-1 determinant. At least two different subtypes of --SEA genotype were observed in this study.
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