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  • Title: Terbutaline sustained-release treatment during one week 5 mg b.i.d. compared to one week placebo: terbutaline plasma levels, c-AMP plasma levels, lung function and tremor measurement.
    Author: van der Vet AP, Kreukniet J, Drost RH, Maes RA, Fokkens JK, Hamelink ML.
    Journal: Int J Clin Pharmacol Ther Toxicol; 1987 Nov; 25(11):609-12. PubMed ID: 2828250.
    Abstract:
    In a group of ten patients with chronic asthmatic bronchitis, a good improvement of the lung function was achieved by a sustained-release terbutaline preparation (Bricanyl Retard) in a dosage of 5 mg twice daily. Tremor measurements and c-AMP plasma level showed a statistically significant increase. A good patient compliance was achieved with this dosage of terbutaline two times daily. The sustained-release preparation caused a rather constant and low terbutaline plasma level. We think that this relative low terbutaline plasma level is the most important reason for the lack of side effects.
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