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  • Title: Dextrorphan: an antagonist for phencyclidine receptor.
    Author: Sun FY, Zhu H, Zhang LM, Xu XR, Zhang AZ.
    Journal: NIDA Res Monogr; 1986; 75():169-72. PubMed ID: 2828965.
    Abstract:
    Radio-binding assay, bioassay and HPLC detection were used to observe the antagonistic effects of dextrorphan on PCP's actions. Dextrorphan displayed high affinity to PCP receptors and it had weak PCP-like bioactivity, but could antagonize PCP's action dose-dependently in vitro and shift the dose-response curve to the right. PCP increased the contents of norepinephrine in bath medium, which was reversed by dextrorphan. Thus, the results suggest that dextrorphan is a partial antagonist for PCP receptors.
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