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  • Title: Effects of prior exposure to morphine on the opioid inhibition of the stimulated release of [3H]norepinephrine from guinea pig cortex slices.
    Author: Werling LL, Brown SR, Cox BM.
    Journal: NIDA Res Monogr; 1986; 75():587-90. PubMed ID: 2829006.
    Abstract:
    The potassium stimulated release of [3H]norepinephrine ([3H]NE) from terminal fields of locus coeruleus projections can be inhibited in a dose-dependent manner by mu and kappa selective opioids. Chronic exposure to morphine for six days decreases the maximum achievable depression by the mu selective agonist Tyr-D-Ala2-Gly-Me(Phe)-Gly-ol (DAGO), but has no effect on the degree of inhibition produced by the kappa selective opioid U50,488H.
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