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  • Title: The effect of L-threo-DOPS on synaptic transmission to soleus motoneuron in normal subjects and patients with Parkinson's disease.
    Author: Nakajima Y, Kagamihara Y, Nagaoka M, Tanaka R.
    Journal: Neurosci Res; 1987 Oct; 5(1):16-27. PubMed ID: 2829065.
    Abstract:
    The effect of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) on synaptic transmission to the soleus motoneurons was studied using the H-reflex method in 12 normal subjects and in 4 patients with Parkinson's disease. A long-lasting depression of the test H-reflex, which was evoked by a conditioning group I volley in the homonymous tibial nerve with an onset latency of ca. 30 ms and a duration of more than 1 s and was regarded to represent the transmitter depletion caused by a preceding volley, diminished significantly after the oral administration of L-threo-DOPS both in the normal subjects and in the patients. On the other hand, no change was recognized in the slow depression which was caused by a group I volley of the heteronymous common peroneal nerve and was regarded as the presynaptic inhibition. The findings suggest that L-threo-DOPS influences the reduction of transmitter depletion.
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