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  • Title: Newly synthesized analogues of the spider toxin block the crustacean glutamate receptor.
    Author: Shudo K, Endo Y, Hashimoto Y, Aramaki Y, Nakajima T, Kawai N.
    Journal: Neurosci Res; 1987 Oct; 5(1):82-5. PubMed ID: 2829068.
    Abstract:
    Effects of synthetic compounds similar to the structure of a spider toxin were studied on the glutamate receptors in crustacean neuromuscular synapses. Two kinds of analogues, 2,4-dihydroxyphenylacetyl-asparaginyl cadaverine (C-1) and 2,4-dihydroxyphenylacetyl-asparaginyl spermine (C-2), suppressed the excitatory postsynaptic potentials in a manner similar to natural spider toxin (JSTX). The dose-response relationship showed that the relative potency of the compounds is C-1 less than C-2 less than JSTX. While the effect of JSTX was irreversible, those of C-1 and C-2 were reversible. These synthetic compounds may serve as important tools in studying the structure and function of glutamate receptors.
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