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  • Title: Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. I. The taxonomy of the producing strain, and the fermentation, isolation and antibacterial activities.
    Author: Fukumoto A, Kim YP, Matsumoto A, Takahashi Y, Suzuki M, Onodera H, Tomoda H, Matsui H, Hanaki H, Iwatsuki M, Ōmura S, Shiomi K.
    Journal: J Antibiot (Tokyo); 2017 May; 70(5):562-567. PubMed ID: 28293038.
    Abstract:
    Screening for circumventors of β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) led us to find 17 novel antibiotics, naphthacemycins A1-A11, B1-B4 and C1-C2. The naphthacemycins were isolated from a cultured broth of Streptomyces sp. KB-3346-5 by repeated silica gel column chromatography and HPLC. Naphthacemycins enhanced imipenem activity 100-500 times against MRSA at 0.5 μg ml-1, and naphthacemycins A4-A11 themselves showed MIC50 values of 1-4 μg ml-1 against 22 MRSA strains.
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