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  • Title: [Cytogenetic activity of chemical compounds in adrenalectomized animals].
    Author: Variliak IR, Saglo VI.
    Journal: Tsitol Genet; 1987; 21(5):343-9. PubMed ID: 2829397.
    Abstract:
    Pyrimethamine, sodium salicylate or ethanol were administered to adrenalectomized rats 3 and 21 days after the operation. It is shown that cytogenetic effect in the operated rats is less pronounced, particularly 3 weeks after the operation. Adrenaline (0.2 mg/kg) increases the effect of chemicals on the chromosome apparatus, while hydrocortisone (50 mg/kg) and corticotropin (10 U/kg) decrease it.
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