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  • Title: Action of trapidil on the heart contractility: relationship to the cyclic nucleotide metabolism.
    Author: Bartel S, Reese D, Krause EG.
    Journal: Biomed Biochim Acta; 1987; 46(8-9):S472-6. PubMed ID: 2829868.
    Abstract:
    The relationship between the cardiotonic action of trapidil (RocornalR) and cyclic nucleotide metabolism was studied in the isolated rat heart. The contractility of the heart was increased in a concentration-dependent manner by this drug (ED50 20/microM). Parallel with the mechanical changes the tissue levels of cyclic AMP were increased, which was associated with an activation of the cAMP-dependent protein kinase. Cyclic GMP was enhanced only at a drug concentration of 1 mM. The present findings support the hypothesis that the cyclic nucleotide system is involved in the functional action of trapidil on cardiac tissue.
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