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  • Title: A prospective study of the role of intralesional bleomycin in orbital lymphangioma.
    Author: Raichura ND, Alam MS, Noronha VO, Mukherjee B.
    Journal: J AAPOS; 2017 Apr; 21(2):146-151. PubMed ID: 28300684.
    Abstract:
    PURPOSE: To evaluate the efficacy of intralesional bleomycin injection in the management of lymphangiomas of the orbit. METHODS: This prospective noncomparative interventional case study included 13 patients with orbital lymphangiomas. Reconstituted bleomycin 1-5 ml (0.5 IU/kg body weight; maximum, 15 IU/ml) was injected with 2% lignocaine in the lesion as seen on imaging or, in deeper lesions, under ultrasound guidance. Repeat injections were administered when required after every 4 weeks. The decision to retreat was based on clinical and radiological evidence of response. RESULTS: Patients were treated with 1-6 injections of bleomycin 0.5 IU/kg body weight. Dramatic response was achieved in all cases. During the mean follow-up period of 19.69 months (range, 7-26 months) none of the patients experienced recurrence or significant complication. CONCLUSIONS: In this patient cohort lymphangiomas of the orbit showed favorable and promising results with intralesional injections of bleomycin. This treatment should be considered as a first-line therapy for lymphangiomas of the orbit.
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