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  • Title: Novel hypoxia-targeting Pt(iv) prodrugs.
    Author: Xu Z, Zhao J, Gou S, Xu G.
    Journal: Chem Commun (Camb); 2017 Mar 28; 53(26):3749-3752. PubMed ID: 28303266.
    Abstract:
    Novel Pt(iv) prodrugs targeting hypoxia inducible factor HIF-1α were prepared for evaluating their antitumor activity on hypoxic cancer cells for the first time. The resulting Pt(iv) prodrug exhibited effective inhibition on tumor growth in the HCT-116 xenograft mouse model with low toxicity in vivo.
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