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  • Title: Tonometer validation and intraocular pressure reference values in the normal chinchilla (Chinchilla lanigera).
    Author: Snyder KC, Lewin AC, Mans C, McLellan GJ.
    Journal: Vet Ophthalmol; 2018 Jan; 21(1):4-9. PubMed ID: 28303681.
    Abstract:
    OBJECTIVES: To determine accuracy and precision of three commonly used tonometers (TonoVet® and TonoLab® (ICare Oy, Finland)-rebound tonometers, and Tono-Pen VET™ (Reichert, NY)-applanation tonometer) in normal chinchillas, and to establish a normal intraocular pressure (IOP) reference range in this species. METHODS: The anterior chambers of three chinchilla eyes were cannulated ex vivo and readings obtained at manometric IOPs from 5 to 80 mmHg, using each of the three tonometers in random order. Data were analyzed by linear regression, ANOVA, and Bland-Altman plots. Tonometry was performed in both eyes of 60 chinchillas (age 8 weeks-16.2 years) using the TonoVet® and relationship between age and IOP analyzed using linear regression. For all statistical tests, P < 0.05 was significant. RESULTS: Intraocular pressure values obtained using the Tono-Pen VET™ and TonoVet® (in dog calibration mode;'d') showed strong linear correlation with manometry within the physiologic and clinically relevant range of IOP (0-50 mmHg). The TonoVet® 'd' setting displayed significantly greater precision over the full range of IOP evaluated than the Tono-Pen VET™, and both TonoVet and Tono-Pen VET™ were significantly more accurate than the TonoLab® tonometer. Mean ± SD IOP (TonoVet® 'd') in chinchillas was 9.7 ± 2.5 mmHg, and the 95% reference interval was 4.7-14.7 mmHg. CONCLUSIONS: Both the Tono-Pen VET™ and TonoVet® provided clinically acceptable estimates of IOP in chinchillas. The TonoVet® provides accurate and precise IOP values, while Tono-Pen VET™ derived measurements showed greater variability. Values obtained either with the TonoLab® or TonoVet® used in the 'unspecified' calibration setting were inaccurate in this species.
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