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  • Title: Autoradiographic demonstration of gastrin-releasing peptide-binding sites in the rat gastric mucosa.
    Author: Nakamura M, Oda M, Kaneko K, Akaiwa Y, Tsukada N, Komatsu H, Tsuchiya M.
    Journal: Gastroenterology; 1988 Apr; 94(4):968-76. PubMed ID: 2831106.
    Abstract:
    The location of [125I]iodotyrosyl gastrin-releasing peptide-binding sites in the rat fundic mucosa was studied. Peptide specificity was demonstrated by competitive binding studies using the addition of a large amount of cold gastrin-releasing peptide or substance P. Autoradiography of the stomach tissue was carried out by freeze-drying, embedding in Epon, wet-sectioning with ethylene glycol, and dry-mounting the emulsion film by the wire-loop method to prevent loss of the labeled substance. Specific binding sites of gastrin-releasing peptide were found on D cells, surface mucus cells, and parietal cells, whereas few binding sites were seen on the chief or mucus neck cells.
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