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  • Title: Acceleration of recovery from sciatic nerve damage by the ACTH (4-9) analog Org 2766: different routes of administration.
    Author: Dekker AJ, Princen MM, De Nijs H, De Leede LG, Broekkamp CL.
    Journal: Peptides; 1987; 8(6):1057-9. PubMed ID: 2831516.
    Abstract:
    Functional recovery following a sciatic nerve crush in rats was investigated by measuring the reflex withdrawal of the hindpaw to a hot air stream. The ACTH(4-9) analog Org 2766 accelerated recovery when administered subcutaneously (two-daily injections: 10 micrograms/animal; minipumps: 20-40 micrograms/animal per 24 hr: biodegradable microspheres: 40 micrograms/animal per 24 hr), but oral administration (1.5-20 mg/animal daily, in the drinking water; 1.5-15 mg/animal daily, by gavage) was not effective.
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