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  • Title: Cholinergic neurotransmission in human corpus cavernosum. II. Acetylcholine synthesis.
    Author: Blanco R, Saenz de Tejada I, Goldstein I, Krane RJ, Wotiz HH, Cohen RA.
    Journal: Am J Physiol; 1988 Mar; 254(3 Pt 2):H468-72. PubMed ID: 2831739.
    Abstract:
    Physiological and histochemical evidence indicates that cholinergic nerves may participate in mediating penile erection. Acetylcholine synthesis and release was studied in isolated human corporal tissue. Human corpus cavernosum incubated with [3H )choline accumulated [3H]choline and synthesized [3H]acetylcholine in a concentration-dependent manner. [3H]Acetylcholine accumulation by the tissue was inhibited by hemicholinium-3, a specific antagonist of the high-affinity choline transport in cholinergic nerves. Transmural electrical field stimulation caused release of [3H]acetylcholine which was significantly diminished by inhibiting neurotransmission with calcium-free physiological salt solution or tetrodotoxin. These observations provide biochemical and physiological evidence for the existence of cholinergic innervation in human corpus cavernosum.
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