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  • Title: Lonidamine-induced outer membrane permeability and susceptibility of mitochondria to inhibition by adriamycin.
    Author: Floridi A, Bianchi C, Bagnato A, Gambacurta A, Paggi MG, Silvestrini B, Caputo A.
    Journal: Anticancer Res; 1987; 7(6):1149-52. PubMed ID: 2831790.
    Abstract:
    Low concentrations of Adriamycin (ADM) do not inhibit the oxygen consumption of rat liver mitochondria because of the inability to cross the outer membrane. The involvement of this membrane as a permeability barrier is demonstrated by the results with exogenous ferrocytochrome c. ADM does not affect the basal rate of ferrocytochrome c oxidation, which, on the contrary, increases in Lonidamine (LND)-treated mitochondria. This difference lies in the capacity of LND to unmask the redox carriers in the inner membrane, i.e. cytochrome c:oxygen oxidoreductase which is also a marker of the outer membrane permeabilization. Therefore, the enhancement of ADM's effect on mitochondrial respiration by LND must be ascribed to its permeabilizing effect on the outer mitochondrial membrane.
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