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  • Title: [High-irradiance accelerated corneal collagen crosslinking for the treatment of keratoconus: A retrospective study].
    Author: Moineau N, Sauvan L, Benichou J, Ho Wang Yin G, Hoffart L.
    Journal: J Fr Ophtalmol; 2017 Apr; 40(4):319-328. PubMed ID: 28318708.
    Abstract:
    PURPOSE: To evaluate the safety and efficacy of accelerated corneal collagen crosslinking on stabilization of progressive keratoconus. MATERIALS AND METHODS: This was a retrospective study from March 2013 to March 2015. Patients with progressive keratoconus who underwent accelerated corneal collagen crosslinking were included. Visual acuity with and without correction, biomicroscopy, corneal elevation topography (maximum and mean keratometry values, minimum pachymetry, densitometry) and side effects were recorded at baseline and at 1, 3 and 6 months (M). RESULTS: One hundred and ten eyes of 84 patients were included. At month 6, we found an improvement in corrected distance visual acuity (CDVA) with a small improvment of 0.069±0.15 logMAR (P=0.009). Uncorrected distance visual acuity remained unchanged. The mean minimum corneal pachymetry was 455μm at baseline and 449μm at m6 (P<0.001). There was no statistically significant difference between pre- and postoperative mean keratometry values (M1, M3, M6). We likewise found no difference in maximum keratometry between pre- and postoperative values at M1, M3 and M6 (P>0.1). With regard to safety, we report 1 case of postoperative infectious keratitis and 1 case of anterior non-granulomatous uveitis after treatment in patients without any known past ocular history. DISCUSSION: The results we found in this study after accelerated corneal crosslinking are similar to those with conventional crosslinking protocols published in the literature. CONCLUSIONS: High irradiance accelerated corneal collagen crosslinking appears to be a reliable and effective therapeutic alternative for progressive keratoconus, allowing for a more brief procedure.
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