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  • Title: [Treatment of arterial occlusions of the lower extremities using 2-stage local application of urokinase].
    Author: Gross-Fengels W, Neufang KF, Lechler E, Schmitz-Rixen T.
    Journal: Rofo; 1988 Mar; 148(3):269-74. PubMed ID: 2832890.
    Abstract:
    We report the results of a 2-phase urokinase protocol for treatment of 28 arterial occlusions of the lower extremities. 26 patients, aged 43-86, with up to 6 weeks old occlusions were treated. In Phase I (average duration 2.7 h) the urokinase solution was injected in intervals directly into the occlusion-material via a F-5 catheter (120,000 U/h). In the following phase II (average duration 26.1 h) 100,000 U/h were given as a continuous arterial infusion and a full heparin regimen was started. In 86% of the treatments there was an improvement as shown by angiography. 75% of the patients could be released from the hospital without a further surgical revascularisation. Alterations of the systemic coagulation-system and bleeding-complications at the puncture site must be expected.
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