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  • Title: [Weakening of type I restriction in E. coli: the effect of 2-aminopurine and 5-bromouracil].
    Author: Belogurov AA, Efimova EP, Del'ver EP, Zavil'gel'skiĭ GB.
    Journal: Mol Gen Mikrobiol Virusol; 1987 Dec; (12):34-40. PubMed ID: 2833697.
    Abstract:
    2-aminopurine (2-AP) and 5-bromouracil, strong mutagens of base analog type, were found to induce efficiently the alleviation of I type restriction in Escherichia coli. 2-AP induced restriction alleviation occurs in recA, lexA and mut- mutants, but no additional relief of restriction is registered in dam-bacteria in the presence of sublethal 2-AP concentrations. 2-AP specifically alleviates I type restriction in Escherichia coli (EcoA, EcoB, EcoD, and EcoK) and does not affect restriction systems of II (EcoRI) and III (EcoP1) types. We suggest that 2-AP-induced mismatches and other replication errors may be signals inducing restriction alleviation in Escherichia coli.
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