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  • Title: Anti-RH immunoglobulin therapy for human immunodeficiency virus-related immune thrombocytopenic purpura.
    Author: Oksenhendler E, Bierling P, Brossard Y, Schenmetzler C, Girard PM, Seligmann M, Clauvel JP.
    Journal: Blood; 1988 May; 71(5):1499-502. PubMed ID: 2833961.
    Abstract:
    The potential hazards of steroids in human immunodeficiency virus (HIV)-infected patients led us to evaluate the effectiveness and safety of anti-D and anti-c Ig in 17 adults with severe HIV-related immune thrombocytopenic purpura (platelet count less than 20 x 10(9)/L). The 14 Rh+ patients received 12 to 25 micrograms/kg of anti-D IgG intravenously on two consecutive days. A significant platelet rise above 50 x 10(9)/L was obtained in nine patients. Repeated boosters were performed in six cases and were effective in all cases. The 3 Rh- patients had a good response after they were given 20 mL x 2 of plasma containing potent anti-c antibodies. Therapy was well tolerated, and only one patient had significant hemolysis. These data suggest that anti-Rh IgG can be effective and safe in HIV-related thrombocytopenic purpura and that a specific interaction between the RBC antigens and the anti-Rh antibodies is required.
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