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  • Title: Effects of ZSY-27, a synthesized phosphodiesterase inhibitor, on exocrine secretion and cyclic nucleotide concentration in the dog pancreas.
    Author: Iwatsuki K, Horiuchi A, Chiba S.
    Journal: Clin Exp Pharmacol Physiol; 1987; 14(11-12):915-8. PubMed ID: 2834125.
    Abstract:
    1. Effects of intravenous injections of ZSY-27, a synthesized phosphodiesterase inhibitor, on pancreatic exocrine secretion and on pancreatic cyclic AMP and cyclic GMP concentrations of dogs were investigated. 2. ZSY-27 (0.3 and 1 mg/kg) increased cyclic AMP concentration dose-dependently, which preceded the increase in pancreatic secretion but did not affect cyclic GMP concentration. 3. These results suggest that ZSY-27 causes exocrine secretion from the dog pancreas mediated through an increase in intracellular cyclic AMP concentration.
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