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  • Title: Case of bullous pemphigoid coexisting with anti-desmoglein autoantibodies.
    Author: Tie D, Yoshida T, Chinuki Y, Da X, Ishikawa N, Morita E.
    Journal: J Dermatol; 2017 Jul; 44(7):822-825. PubMed ID: 28342216.
    Abstract:
    A 79-year-old Japanese woman had clinical and histopathological features of bullous pemphigoid, while direct immunofluorescence test revealed C3 and immunoglobulin G depositions in the lower cell surfaces of the epidermis in addition to those in the dermoepidermal junction. Chemiluminescent enzyme immunoassays were positive for desmoglein-1 and -3 antibodies in addition to anti-BP180 antibodies. In an immunoblotting study, antibodies against both 180-kDa bullous pemphigoid antigen and 130-kDa pemphigus vulgaris antigen were detected. Based on these results, bullous pemphigoid coexisting with anti-desmoglein autoantibodies was diagnosed in this case.
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