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  • Title: G protein coupling of antigen receptor-stimulated polyphosphoinositide hydrolysis in B cells.
    Author: Harnett MM, Klaus GG.
    Journal: J Immunol; 1988 May 01; 140(9):3135-9. PubMed ID: 2834452.
    Abstract:
    Cross-linking of the IgM and IgD Ag-R on mature B lymphocytes provokes the rapid hydrolysis of phosphatidylinositol 4,5-bisphosphate. We show here that in permeabilized, [3H]inositol-labeled mouse B cells the nonhydrolyzable GTP analogue GTP gamma S induces release of inositol phosphates, including inositol trisphosphate. The response is markedly augmented by the addition of polyclonal anti-Ig or anti-mu or anti-delta mAb. Inositol phosphate release provoked in intact B cells by any of the anti-receptor antibodies was not inhibited by pertussis toxin and only partially inhibited by cholera toxin. The results therefore indicate that both IgM- and IgD-R on B cells are coupled to the polyphosphoinositide-specific phosphodiesterase by one or more G proteins, which have yet to be identified.
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