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  • Title: Different plasticity changes in D1 and D2 receptors in rat striatal subregions following impairment of dopaminergic transmission.
    Author: Savasta M, Dubois A, Benavidès J, Scatton B.
    Journal: Neurosci Lett; 1988 Feb 15; 85(1):119-24. PubMed ID: 2834672.
    Abstract:
    The precise topographical changes in striatal D1 and D2 dopamine receptor density that occurred after chronic treatment with haloperidol or SCH 23390 or after 6-hydroxydopamine-induced lesion of the mesostriatal dopaminergic pathway have been studied autoradiographically in the rat. Repeated treatment with SCH 23390 (0.5 mg/kg i.p., 21 days) caused an almost similar increase in [3H]SCH 23390 binding sites in the different striatal subregions whereas lesion of the dopaminergic pathway was ineffective. Subacute administration of haloperidol (2 mg/kg i.p., 18 days) or lesion of dopaminergic afferents provoked an increase in [3H]spiperone binding which was restricted to the ventro- and dorsolateral striatal sectors.
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