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  • Title: Malignant acrospiroma: a case report in the era of next generation sequencing.
    Author: Diab M, Gabali A, Kittaneh M.
    Journal: BMC Cancer; 2017 Mar 27; 17(1):221. PubMed ID: 28347286.
    Abstract:
    BACKGROUND: Malignant acrospiroma is a rare tumor of the eccrine sweat glands accounting for around 6% of all malignant eccrine tumors. Typically, it presents as large ulcerated nodules, and diagnosis can be challenging as it has great overlap with its benign counterpart. CASE PRESENTATION: We herein report a case of acral malignant acrospiroma, initially treated with surgical excision and adjuvant radiotherapy. After metastatic disease was confirmed, subject received multiple lines of chemo- as well as targeted therapy. Genomic testing was also done using next generation sequencing. CONCLUSION: To the best of our knowledge, this is the first case of acral malignant acrospiroma with reported next generation sequencing results.
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