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  • Title: Toxicity trial of prophylactic 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine (ganciclovir) after marrow transplantation in dogs.
    Author: Appelbaum FR, Meyers JD, Deeg HJ, Graham T, Schuening F, Storb R.
    Journal: Antimicrob Agents Chemother; 1988 Feb; 32(2):271-3. PubMed ID: 2834998.
    Abstract:
    The effects of 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine, or ganciclovir, administered during the immediate posttransplant period to dogs given total-body irradiation and autologous marrow transplants were studied. Doses of ganciclovir of 3.0 mg/kg (body weight) per day were well tolerated without detectable delay in hematopoietic recovery, whereas doses of 5.0 mg/kg per day were associated with delayed platelet recovery.
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