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  • Title: Mutual inactivation of valinomycin and protonophores by complex formation in liposomal membranes.
    Author: Krishnamoorthy G.
    Journal: FEBS Lett; 1988 May 09; 232(1):199-203. PubMed ID: 2835269.
    Abstract:
    The stimulation presence of a protonophore [3,5-di(ter-butyl)-4-hydroxybenzylidenemalononitrile or carbonyl cyanide m-chlorophenylhydrazone] and valinomycin in a liposome suspension results in time-dependent inactivation of ion transport by both the protonophore and valinomycin. Correlation of the inactivation with spectrophotometric observations on the formation of a complex between the protonophore and valinomycin strongly suggests that the complex observed has no (or very low) activity for the transport of either H+ or K+. The stoichiometry of valinomycin and the protonophore in the inactive complex is shown to be 1:1.
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