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  • Title: Clinical characteristics of patients with cerebellar ataxia associated with anti-GAD antibodies.
    Author: Aguiar TS, Fragoso A, Albuquerque CR, Teixeira PF, Souza MV, Zajdenverg L, Alves-Leon SV, Rodacki M, Lima MA.
    Journal: Arq Neuropsiquiatr; 2017 Mar; 75(3):142-146. PubMed ID: 28355320.
    Abstract:
    METHODS: This retrospective and descriptive study evaluated the clinical characteristics and outcomes of patients with CA-GAD-ab. RESULT: Three patients with cerebellar ataxia, high GAD-ab titers and autoimmune endocrine disease were identified. Patients 1 and 2 had classic stiff person syndrome and insidious-onset cerebellar ataxia, while Patient 3 had pure cerebellar ataxia with subacute onset. Patients received intravenous immunoglobulin therapy with no response in Patients 1 and 3 and partial recovery in Patient 2. CONCLUSION: CA-GAD-ab is rare and its clinical presentation may hamper diagnosis. Clinicians should be able to recognize this potentially treatable autoimmune cerebellar ataxia.
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